Melanotan II is an analogue of the peptide hormone alpha-melanocyte-stimulating hormone (a-MSH) that induces skin tanning. It was originally developed by the University of Arizona in the 1980’s to treat people who were intolerant to the sunlight. Melanotan II plays a role in melanogenesis in protecting the skin from UV light. There are 5 melanocortin receptors each with a different function. MT 2 binds primarily to MC-4R and MC-1R, and weakly to MC-3R.
MC-1R is found on the melanocytes, stimulation causes darkening of skin and hair.
MC-2R is found on the adrenal glands, binding to MC-2R promotes secretion of adrenal hormones such as cortisol. MC-3R involved in appetite control and energy regulation MC-4R stimulation causes changes in feeding and sexual behavior, and also affects male erectile function and energy homeostasis.
Inject 0.15ml daily for 1 – 2 weeks then 0.25mL twice weekly for maintenance